資訊中心NEWS CENTER
在發(fā)展中求生存，不斷完善，以良好信譽(yù)和科學(xué)的管理促進(jìn)企業(yè)迅速發(fā)展
差向異構(gòu)化是指在化學(xué)反應(yīng)中，一個(gè)差向異構(gòu)體（epimer）轉(zhuǎn)化為另一個(gè)差向異構(gòu)體或其手性對(duì)映體的過程。在肽合成中，氨基酸的差向異構(gòu)化是一個(gè)常見的副反應(yīng)，可能導(dǎo)致肽的整體構(gòu)象改變，從而影響其生物活性。差向異構(gòu)化產(chǎn)物與目標(biāo)肽在物理特性上高度相似，增加了純化的難度。在多肽合成及多肽藥物...
INTRODUCTIONTheN-α-Fmoc-α-aminoisobutyricacidderivative（Aib）isadifficultderivativeforcouplinginSPPSduetoitssecondmethylgroupontheα-carbonthatinterfereswiththecouplingreaction（Figure1）.However,itcanbefoundinanumberofbiologicallyrelevantcompo...
查看詳情INTRODUCTIONTheAKR/Grossmurineleukemiaviruses（MuLV）areC-typeretrovirusesthatcausethedevelopmentofleukemiainAKR（H-2k）mice.1Type-specificantiretroviralcytotoxicT-lymphocyte（CTL）responseshavebeenreportedthatallowdifferentiationbetweeninfection...
查看詳情INTRODUCTIONInthedevelopmentofantibodiesdirectedagainstspecificpeptidesequences,T-helperepitopesareoftentaggedontothepeptidesequencetoaidinthestimulationoftheimmuneresponse.OnesuchsequenceistheuniversalPanHLADR-bindingepitope（PADRE）.Synthes...
查看詳情INTRODUCTIONOnechallengefacingpeptidesynthesisisthe-lactamformationofarginine（Figure1）.Theformationof-lactamoccurswhentheinternalnitrogenoftheguanidineattackstheactivatedester,irreversiblyformingthelactamring.Thisreactioniscompetitivewithpe...
查看詳情INTRODUCTIONOnepotentialissueinpeptidesynthesisisracemizationofcysteineａndhistidine.Thisisaconcernformicrowavepeptidesyntheisbecauseoftheelevatedtemperaturesduringdeprotectionａndcoupling.Studieshaveshownthatloweringthetemperatureto50°Cdurin...
查看詳情INTRODUCTIONVIP（vasoactiveintestinalpeptide）,apeptidehormone,hasbeenimplicatedinanumberofbiologicalprocessesincluding:increasingdigestivesystemmotility,stimulatingpepsinogensecretion,controllingthemammaliancircadiantimekeepingmachinery,regu...
查看詳情
SCROLL
聯(lián)系人：高
座機(jī)：010-65528800
地址：北京市朝陽區(qū)吉慶里14號(hào)佳匯國際A202室
快速導(dǎo)航
產(chǎn)品系列
產(chǎn)品推薦
Copyright©2025 培安有限公司 版權(quán)所有 All Rights Reserved 備案號(hào)：京ICP備17026558號(hào)-1 總訪問量：468555
技術(shù)支持：化工儀器網(wǎng) 管理登錄 sitemap.xml
手機(jī)：010-65528800